BCSC 246: Lecture Schedule

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Date
Topic
Reading
01/13
Introduction
1) Defining Mental Illness (Eric Maisel)
2) Book of Woe-DSM-V (Gary Greenberg)
01/18
Neurotransmitters
1) Linden Ch 2
2) Deutch and Roth: Neurochemicals
01/20
Receptors and Transduction
1) Girault, J-A. and Greengard, P. Principles of Signal Transduction, (C & N, Ch. 4) pp. 41-65 (optional)
2) Linden Ch 9
01/25
Neuroplasticity
1) Nestler, E.J. and Hyman, S.E. Mechanisms of Neural Plasticity (C & N, Ch. 5) pp. 66-75;
2) McGill, B.E. and Zoghbi, H.Y. (2009) Epigenetics of Psychiatric Diseases, (C & N, Ch. 8 - focus on pp. 104-110 and 118-121).
01/27
Hormonal Influences on Brain Function
TAKE-HOME PROBLEM SET Handed Out
1) Linden Ch 1
2) Linden Ch 3
3) Linden Ch 7
02/01
Take home exam review
TAKE-HOME PROBLEM SET DUE by 9:40
 
02/03
Huntington's Disease 1
1) Huntington disease. Nature Reviews: Disease Primers
02/08
Huntington's Disease 2
1) Original articles in BB **recommended reading**
2) Linden Ch 6
02/10
Alzheimer’s disease 1
1) Mayeux, R. Early Alzheimer’s Disease NEJM 2010
2) Linden Ch 22
3) Alzheimer disease. Nature Reviews: Disease Primers
02/15
Alzheimer’s disease 2
 
02/17
Alzheimer disease 3: Journal Article Discussion
1) Wang and Li. Dysregulation of synaptic and extra-synaptic NMDA receptors induced by amyloid-beta. 2013
2) Talantova et al. A-beta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. 2013.
02/22
Journal Club
1) Li et. al. Metabotropic Glutamate Receptor 2/3 activation improves motor performance and reduces pathology in HD mice. 2021 J. Pharmacol Exp Ther.
02/24
Parkinson’s Disease 1
1) Linden Ch 22
2) Parkinson disease, Nature Reviews: Disease Primers
03/01
Parkinson’s Disease 2
1) Liu et al, a7-nicotinic AChR-mediated neuroprotection against DA neuron loss, J Neuroinflamm. 2012
2) PD Review-oxidative stress and more
3) Crabtree & Zhang, Genetically engineered mouse models of Parkinson's disease, Brain Res. Bull. 2012
03/03
Parkinson’s Disease 3
1) Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a model of Parkinson's Disease. 2016
2) Smith et al. A neuroscience perspective of the gut theory of PD. 2018
03/08
Spring Break
 
03/10
Spring Break
 
03/15
Journal Club
1) Yu et al. Context-specific striatal astrocyte molecular responses are phenotypically exploitable. Neuron 2020
03/17
EXAM 2
 
03/22
Addiction 1
1) Linden Ch 17
2) Charney and Nestler, Ch 45
3) Koob, et. al. Hedonistic model of addiction. Science 1997
4) Addiction to the DA theory of addiction? Opinion
03/24
Addiction 2
 
03/29
Mood Disorders-Depression 1
1) Major Depressive Disorder, Nature Reviews: Disease Primers
2) Nrn depression N&V on dusp-1
3) Ch 27 Animal Models of Mood Disorders
4) Linden Ch 13
03/31
Mood Disorders-Depression 2
1) Mechawar & Savitz, Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl. Psych. 2016
1) 2) Belleau et al, The impact of stress and Major depressive disorder on Hippocampal and mPFC morphology. 2018
3) Anaker and Hen. Neurogenesis and Cognitive flexibility: effect on mood, NRN 2017
04/05
Journal Club
1) MAPK inhibitor in depression (DUSP-1)
04/07
Anxiety 1
1) Linden, Chs 14 & 15
2) Anxiety Disorders Nature Reviews: Disease Primers
04/12
Anxiety 2
1) Ressler & Mayberg, Targeting abnormal neural circuits in mood and anxiety disorders. Nat Neurosci. 2007
2) Animals and Anxiety Review
04/14
Schizophrenia 1
1) Schizophrenia, Nature Reviews: Disease Primer
2) Bencherif et al. Alpha7 nicotinic cholinergic neuromodulation may reconcile multiple neurotransmitter hypotheses of schizophrenia. Med. Hypotheses 2012.
3) Linden Ch 16 & 24, relevant sections
04/19
Schizophrenia 2
1) Gulchina et al. 2017. Epigenetic mechanisms underlying NMDAR hypofunction…in schizophrenia. J. Neuroche
2) Belforte et al. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat. Neurosci 2010
3) Schizophrenia pruning N&V
4) OPTIONAL: C4 complement in schizophrenia
04/21
EXAM 3
 
04/26
Epilepsy
1) Scharfman, Helen. The Neurobiology of Epilepsy. Curr Neurol Neurosci Rep. July 2007.
2) Epilepsy, Nature Reviews: Disease Primers
3) Joels and Marian. Stress, the HPC, and Epilepsy. 2009.
4) Tan et al. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci. 2012.
05/02
Epilepsy papers Due