01/18

Introduction

1) Defining Mental Illness (Eric Maisel)
2) Book of Woe-DSM-V (Gary Greenberg)

01/23

Neurotransmitters

1) Linden Chapter 2
2) Deutch and Roth: Neurochemicals

01/25

Receptors and Transduction

1) Girault, J-A. and Greengard, P. Principles of Signal Transduction, (C & N, Ch. 4) pp. 41-65 (optional)
2) Linden Chapter 9

01/30

Neuroplasticity

1) Nestler, E.J. and Hyman, S.E. Mechanisms of Neural Plasticity (C & N, Ch. 5) pp. 66-75;
2) McGill, B.E. and Zoghbi, H.Y. (2009) Epigenetics of Psychiatric Diseases, (C & N, Ch. 8 - focus on pp. 104-110 and 118-121).

02/01

Hormonal Influences on Brain Function
AT-HOME PROBLEM SET Available on BB

1) Linden Chapter 1
2) Linden Chapter 3
3) Linden Chapter 7

02/06

Huntington's Disease 1

1) Huntington disease. Nature Reviews: Disease Primers

02/08

Huntington's Disease 2

1) Original articles in BB **recommended reading**
2) Linden Chapter 6

02/13

HD 3 Journal Club

1) Li et. al. Metabotropic Glutamate Receptor 2/3 activation improves motor performance and reduces pathology in HD mice. 2021 J. Pharmacol Exp Ther.

02/15

Alzheimer’s disease 1

1) Mayeux, R. Early Alzheimer’s Disease NEJM 2010
2) Linden Chapter 22
3) Alzheimer disease. Nature Reviews: Disease Primers

02/20

Alzheimer’s disease 2

1) Recent advances in animal models of AD

02/22

Alzheimer disease 3
Journal Article

1) Wang and Li. Dysregulation of synaptic and extra-synaptic NMDA receptors induced by amyloid-beta. 2013
2) Talantova et al. A-beta induces astrocytic glutamate release extrasynaptic NMDA receptor activation, and synaptic loss. 2013.

02/27

Parkinson’s Disease 1

1) Linden Chapter 22
2) Parkinson disease, Nature Reviews: Disease Primers

02/29

Parkinson’s Disease 2

1) Liu et al, a7-nicotinic AChR-mediated neuroprotection against DA neuron loss, J Neuroinflamm. 2012
2) PD Review-oxidative stress and more
3) Crabtree & Zhang, Genetically engineered mouse models of Parkinson’s disease, Brain Res. Bull. 2012

03/05

Parkinson’s Disease 3

1) Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a model of Parkinson’s Disease. 2016
2) Smith et al. A neuroscience perspective of the gut theory of PD. 2018

03/12

 

03/014

 

03/19

Addiction 1

1) Linden Chapter 17
Charney and Nestler, Chapter 45

03/21

Addiction 2

1) Bogdan et al, The Genetically informed model of addiction 2021 Nature Reviews
2) Koob, et. al. Hedonistic model of addiction. Science 1997

03/26

Mood Disorders-Depression 1

1) Major Depressive Disorder, Nature Reviews: Disease Primers
2) Nrn depression N&V on dusp-1
3) Chapter 27 Animal Models of Mood Disorders
4) Linden Chapter 13

03/28

Mood Disorders-Depression 2

1) Belleau et al, The impact of stress and Major depressive disorder on Hippocampal and mPFC morphology. 2018
2) Anaker and Hen. Neurogenesis and Cognitive flexibility: effect on mood, NRN 2017
3) Castren and Monteggia. BDNF signaling in depression and anti-depressant action. 2021

04/02

Journal Club

1) MAPK inhibitor in depression (DUSP-1)

04/04

Anxiety 1

1) Linden, Chapters 14 & 15*
2) Anxiety Disorders Nature Reviews: Disease Primers

04/09

Anxiety 2

1) Ressler & Mayberg, Targeting abnormal neural circuits in mood and anxiety disorders. Nat Neurosci. 2007
2) Animals and Anxiety Review

04/11

Schizophrenia 1

1) Schizophrenia, Nature Reviews: Disease Primer
2). Bencherif et al. Alpha7 nicotinic cholinergic neuromodulation may reconcile multiple neurotransmitter hypotheses of schizophrenia. Med. Hypotheses 2012.
1) 3) Linden Chapter 16 & 24, relevant sections

04/16

Schizophrenia 2

1) Gulchina et al. 2017. Epigenetic mechanisms underlying NMDAR hypofunction…in schizophrenia. J. Neuroche
2) Belforte et al. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat. Neurosci 2010
3) Schizophrenia pruning N&V
OPTIONAL: C4 complement in schizophrenia

04/18

Epilepsy

Scharfman, Helen. The Neurobiology of Epilepsy. Curr Neurol Neurosci Rep. July 2007.
2) Epilepsy, Nature Reviews: Disease Primers
3) Joels and Marian. Stress, the HPC, and Epilepsy. 2009.

04/23

Journal Club

Tan et al. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci. 2012.

04/30

Glia

1) Han et al. Forebrain engraftment of human glia cells. 2013
2) Tsai et al. High Fat Diet induces depression-like phenotype via astrocytes. 2022
3) Yao et al. HFD induces depression & HPC neurogenesis defects with microglia activation. 2022

05/03

Glia papers
Due May 3 at 4:00pm